Our Story

We launched in 2019 with a simple conviction: the next generation of category-defining companies would be built at the intersection of core science, proprietary technology, and exceptional founders.

Our roots began in the Caltech entrepreneurial community, where breakthrough research, deep technical talent, and a highly supportive innovation ecosystem created a powerful starting point. Today, that foundation has expanded to include the broader California innovation corridor, including Berkeley and UCSF, where world-class science, engineering, and life sciences research continue to produce transformative company opportunities.

With $100M in AUM, we’ve invested in over 40 companies across deep tech, AI, machine learning, life sciences, and other advanced technologies. Our portfolio reflects our belief that proprietary IP, technical depth, and modern AI-enabled execution can help founders move from lab to market faster, more efficiently, and with the potential to create entirely new categories.

Our Values
Learn more about the five core values that guide us
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Our Investment Model

From sourcing to support, our model is tailored to the needs of high-potential science-driven companies.


01

Connect

Develop deal flow in high quality scientific communities underserved by venture capital

02

Invest

Deploy capital at early stage human and planetary health companies enabled by AI and ML

03

Support

Serve founders and teams with non-science value add including fundraising, marketing, hiring and strategy

Where breakthrough science becomes category-defining companies

Freeflow invests in founders translating core science, AI and proprietary technology into category-defining companies. Rooted in Caltech, Berkeley and UCSF, we help breakthrough ideas move from the lab to the World.

Our numbers

Our investment segments represent the core areas where we apply our expertise and strategic insights to deliver optimal value. By focusing on these carefully selected market segments, we identify unique opportunities aligned with our clients' objectives.


$100M

AUM

Three funds to date: Fund One ($25M), Fund Two ($35M) and in early 2024, we closed our first Opportunity Fund at $15M. We also offered additional SPVs for breakout companies.

40+

Portfolio companies

We've invested in more than 40 companies at pre-seed, seed, Series A and Series B rounds. Deep tech that leverages computer science is our core thesis.

100+

Co-investors

Our companies continually attract co-investors from venture and corporate capital. We also regularly provide co-investment opportunities as companies grow and offer new value.

News

Freeflow Expands Into the UCSF Ecosystem

June 2026

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Press Release

Freeflow Ventures Raises $90M In Funding For Early Stage Deep Tech Investments

June 2024

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Investment

Captura

Captura is a revolutionary system for capturing carbon dioxide from ocean water at scale.

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Investment

NeuraNova

Transforming neurovascular assessment using innovative, rapid and portable medical devices

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Founder's Session

Iambic Therapeutics

Iambic Therapeutics has created a disruptive platform for small-molecule drug discovery by harnessing leadership in physics-informed AI and tightly integrating AI-driven design and experimental execution.

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Founder's Session

Hydrosat

Hydrosat uses satellite imagery to provide geospatial intelligence for food security, public safety, and the environment.

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Browse our Investments

Within our portfolio of human and planetary health companies, there's a common drive to solve big problems across a wide range of industries and sectors.

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News

Architecting the Big Capital Raise: Learnings from Deep Tech Venture

April 2023

On the long path to success, a fork in the road many startups face is securing the right investment at the right time. We believe the next trillion dollar companies come from the deep tech themes of Human and Planetary Health.

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Founder's Sessions

We regularly post content and news from our portfolio companies and the Freeflow team.

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